Still, Biotivia was uised in a small study to show that pre-diabetes was controlled with resveratrol at 1000mg a day and a larger study is underway. No one bothered to even post that at imminst.org, likely because Revgenetics is their sponser. Or maybe they aren't interested in human results.

Sirtis has a new study out that seems to show the pfizer study was wrong about resveratrol and the compounds at GSK not directly influencing Sirt1.

Check out In the Pipeline where Derek Lowe had several posts on the Pfizer study in winter, but a week later has said nothing about the new Sirtris study. We all know Mr. Lowe doesn't work at GSK but "another" big pharma company. It will be interesting to see what he and others have to say when he does comment on the paper. Lowe was quite sure Sirtris doesn't have the goods. He may be right, but still too early to tell.

And Westphal, Sinclair's partner, being reprimanded for selliing a type of SRT501… Anyone reading that story knows something is very fishy there. It is possible that no SRT501 type resveratrol was ever sold. And why were they selling "at cost" and only selling in 6 month packages? Every other maker lets a person buy a month at a time.

Selling in 6 month packages requiring $270 is very strange considering all other vendors have been selling 1 month supplies. anyone curious enough to follow up?

Anyway, the resveratrol story isn't over yet.

It looks like Healthy Lifespan, the non-profit headed up by Westphal and Dipp, is selling SRT 501 or a version of it at cost and won't make a profit: 

"The nonprofit’s supplements are made the same way as the formulation of resveratrol that Sirtris initially developed as a drug called SRT501 for Type 2 diabetes, cancer, and other diseases, Dipp says. While the chemical formula for the supplement is the same as the drug, the group’s resveratrol supplements are being offered as just that: dietary supplements, not drugs for specific diseases. That means the group can sell resveratrol just like any other dietary supplements without doing FDA-sanctioned clinical trials to get permission to begin sales.

"Dipp—who formed the Healthy Lifespan Institute with Westphal and others last year—says that their group is the only one she knows of that manufactures resveratrol in a completely synthetic process with the same high standards for sterilization and purity that govern pharmaceutical production.

The article adds that Sinclair and Westphal take SRT 501 , but Dipp doesn't take any resveratrol for personal reasons.

"Former Sirtris Execs’ Nonprofit Starts Selling Resveratrol with Potential Anti-Aging Effects Online"

http://www.xconomy.com (source of Sirtis news)

Resveratrol was found to be effective to an extent against pre-diabetes this spring, but a "preliminary result."

"It is a small study and needs to be confirmed, as other studies with this drug have been negative," Vivian Fonseca, MD, of Tulane University, told MedPage Today.

For their study, the researchers recruited 10 patients ages 60 to 80 who had impaired glucose tolerance.

Over four weeks, patients took one of three doses of resveratrol (1g, 1.5g, or 2g) with a standard meal that included 110 grams of carbohydrates, 20 grams of protein, and 20 grams of fat."

The researchers said the results didn't vary by dose, so they combined the data for the analysis.

 [This is good news since it provides evidence that 1g of resveratrol is as good as 1.5g or 2g, so a person can take less for pre-diabtes. The next larger study should try 250mg, 500mg and 1000mg] 

"She and colleagues found that after four weeks of resveratrol supplements, fasting plasma glucose was unchanged, but both peak post-meal glucose and three-hour glucose area under the curve declined (185 mg/dL versus 166 mg/dL, and 469 versus 428, respectively, P=0.001)."

This is what Dr. Sinclair told the New York Times last August:

  “the results from the Sirtris compounds are promising and will be submitted for publication in coming months.”

It has been almost a year, and from what I can tell, almost nothing has been published. Dr. Westphal said a few weeks ago a paper was being submitted, so maybe that is under review.

The SRT 501 multipe meyeloma trial was suspened this spring because some patients developed kidney problems. It isn't clear that SRT 501 was the reason, and maybe it is good news that some patients wanted to keep taking it. Note also that SRT 501 results for the liver/colon cancer trial were never published after the study ended last December.

So there isn't much good news coming out of GSK/Sirtis recently, but maybe that will change soon. Interesting that the book was delated a year,  though.

Dr. Sinclair was writing a book called Just in Time, scheduled for July 2010. Here is a quote from Forbes:

 "We have split the atom in this field," he (Sinclair) proclaims. "It could be one pill for 20 diseases at once." He figures the compounds will save trillions in medical costs as people live to a ripe old age with few health problems. He is writing a book on his vision: Just in Time.

[further down the article] But just when you think he (Sinclair) is about to go too far, he backs off, admitting that it is possible that the sirtuin research won't pan out in humans. "I don't know if it is me who is going to be successful," he says. A moment later he is insisting that if not he, then someone will eventually develop drugs against aging.

If this site is correct, the book has been delayed a year:

Publisher: Free Press (Oct 2011)

http://www.flipkart.com/just-t.....1439135762

I currently use both products and and I'm looking for some non-hyped up reviews

thanks bdawg

Looks like bad news...

Is the Healthy Lifespan Institute dead?  I might contribute money  but not sure of the benefits??  Any insights would be appreciated.