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10:59 am
January 7, 2010
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RevGenetics
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| Member | posts 93 |
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Some Resveratrol benefits certainly appear to be dose depndent, if you are a healthy individual… simply stick with what you know, and wait for more information.
Cheers
A
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5:53 am
January 7, 2010
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Postak
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2tender said:I think that Sirtuin activation is secondary to the overall effect of Resveratrol. Activation may occur at a lesser level than previously hoped for or suggested. I wouldnt worry about it. With Resveratrol the positives outweigh the negatives when considering the risk, reward ratio. Another idea to consider is taking breaks from all supplementing, as I am doing now. It gives the physiology time to adjust, and re-enhances the effects of supplementing. Just my thoughts and opinions. I hope that helps you.
- Activation may occur at a lesser level than previously hoped for or suggested.
I wouldnt worry about it
- With Resveratrol the positives outweigh the negatives when considering the risk, reward ratio
- as I am doing now. It gives the physiology time to adjust, and re-enhances the effects of supplementing
Offcourse this is all utter bullshit. You remind me of a football supporter who, instead of singing different songs to support his team, got stuck singing the resveratrol song.
considering the risk reward ratio hahaha….that made me LMAO
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12:18 am
December 30, 2009
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2tender
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| Member | posts 51 |
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You flatter me. My statements sound like scientific fact? I wouldnt worry about it, its only your perception and probably not one thats shared by most readers. Perhaps you can match Revgens informative posting here. Have you heard of Quasimodo and the bells? The Ringing of the bells…..
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9:51 pm
December 29, 2009
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FM2020
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| Member | posts 82 |
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2tender said:I think that Sirtuin activation is secondary to the overall effect of Resveratrol. Activation may occur at a lesser level than previously hoped for or suggested. I wouldnt worry about it. With Resveratrol the positives outweigh the negatives when considering the risk, reward ratio. Another idea to consider is taking breaks from all supplementing, as I am doing now. It gives the physiology time to adjust, and re-enhances the effects of supplementing. Just my thoughts and opinions. I hope that helps you.
2tender, my understanding is that you are not a scientist. How can you make claims like "I wouldn't worry about it" or "the positives outweigh the risks…"? You do not know that. As you say, it is only your opinion as a non scientist. Please stop making it sound like fact to those who have raised concerns.
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3:33 pm
December 29, 2009
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RevGenetics
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| Member | posts 93 |
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Hi Stevie:
Hmm… a quick look at google scholar can really provide a lot of info for folks. From the amount of publications about Resveratrol and P53, I would say their appears to be more positive ones about your main concern than not:
Google scholar link
Here are just some on the first page of the search:
Resveratrol-induced Activation of p53 and Apoptosis Is Mediated by Extracellular- Signal-regulated Protein Kinases and p38 Kinase:
http://cancerres.aacrjournals……/61/4/1604
Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway
http://carcin.oxfordjournals.o…..t/20/2/237
Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse:
http://www3.interscience.wiley…..p;SRETRY=0
Resveratrol Increases Nitric Oxide Synthase, Induces Accumulation of p53 and p21WAF1/CIP1, and Suppresses Cultured Bovine Pulmonary Artery EndothelialCell Proliferation by Perturbing Progression through S and G21
http://cancerres.aacrjournals……59/11/2596
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12:06 pm
December 29, 2009
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2tender
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| Member | posts 51 |
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I think that Sirtuin activation is secondary to the overall effect of Resveratrol. Activation may occur at a lesser level than previously hoped for or suggested. I wouldnt worry about it. With Resveratrol the positives outweigh the negatives when considering the risk, reward ratio. Another idea to consider is taking breaks from all supplementing, as I am doing now. It gives the physiology time to adjust, and re-enhances the effects of supplementing. Just my thoughts and opinions. I hope that helps you.
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8:09 am
December 29, 2009
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stevie57
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Hi Forum,
since I've heard about resveratrol and it's high potential I'm watching all news I find
from the internet. There are some confusing news I've read on a serious website, here's just a short excerpt:
"Apart from all the beneficial effects, SIRT1 activation has at least one property with a Janus head, i.e. it can be good or bad. That is the SIRT1 catalyzed deacetylation of the tumour suppressor protein p53 (Vaziri et al., 2001) that leads to inactivation of p53. That is good for normal cells because it increases their survival and prolongs life span, but it is not so desirable for tumorous cells because it has there the same effect: it might stimulate the survival and replication of tumour cells. Actually, SIRT1 appears to be up-regulated in most cancer cells, e.g. in human lung cancer, prostate cancer, leukaemia, in cancer cell lines, and in tissue samples from colon carcinoma (reviewed in Ashraf et al., 2006; Lim, 2006; Stünkel et al., 2007; Fraga and Esteller, 2007; Jung-Hynes et al., 2009). Re-activating p53, i.e. inhibiting SIRT1 instead of stimulating it, could trigger strong apoptosis in tumour cells, and thus could eliminate tumours"
The sites this citation is from is: http://www.biologie.uni-freibu…..itors.html
Further, the author of this site wrote as a conclusion:
"I admit that I was a bit shocked after looking at these publications because I was not aware of the aspect that SIRT activators might have a positive effect on cancer or tumourous growth. Most of the literature on resveratrol deals with its benefits.
The paper by Jang et al. (1997) on the cancer chemopreventive activity of resveratrol was certainly one of the major triggers. This was followed by a flurry of optimistic publications, including a few years later the identification of sirtuins as major targets of resveratrol. At first sight, it seems that the publications reporting on the possible benefits rarely mention or know about the possible side effects, or possibly do not take that seriously.
Regardless of that, my advice would be: if you are thinking about taking resveratrol regularly, it would be good to talk to your Doctor about that (taking for granted that he is up to date with the recent literature).
I think this would be highly advisable if one has a family history of cancer/tumours in the family. Or if you happen to be not so young anymore: who can be sure that one does not have some degenerated cells in his body?"
Can anybody comment that?
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