Forum

Post edited 7:34 pm – November 15, 2009 by FM2020

I think there is a reason Dr. Sinclair has made his comments with respect to a 250mg maximum and that more would be "venturing into greater unkown territory."

A scientist recently commented at the Immt Institute resveratrol forum with respect to a new study on resveratrol activating SRT1

"[The study] just seems like confirmation to me, that resveratrol operates under the conditions of hormesis within the mammalian body. too much is a bad thing, and a little dose can induce positive changes. hence, a low dose of resveratrol might be suitable."

http://www.imminst.org/forum/R…..34125.html

Post edited 8:55 pm – November 11, 2009 by FM2020

Revgenetics posted Dr. Sinclair's 250mg-500mg statement on the resveratrol forum at Immortality Institute without providing the context provided on this forum. In his ebook, he states to consider 250 mg as a maximum.

 When RevGenetics specifically asked Dr. Sinclair about this, Dr Sinclair responded on that thread,  "Revegenetics – one reason may be that the human studies are only short term (~3 mo) and the long term effects of resveratrol in healthy people over years are not yet known.Taking more than 250 mg, therefore, is venturing into greater unknown territory, which might be safe but would be a personal choice."

As of today, Dr. Sinclair is obviously sticking with his 250mg maximum recommendation as the above is his latest statement. If he updates this in the future, then it is worth noting.  

Post edited 8:26 am – November 16, 2009 by RevGenetics

FYI folks: there is a thread here that states the following from Dr. Sinclair. This information is more recent than the eBook you download in the link above. "which might be safe but would be a personal choice."

That is the beauty of these forums. We can be updated almost instantly about the current thinking and suggested dosages.

Thread: "How much resveratrol should I take?"

Posted By: Davids

First Post says:

"The e-book download goes into this in detail – it states that the doses based on the mouse studies are 250 -500 mg per day. There are a few reports of resveratrol thinning the blood. I've not read any severe side effects of 1 gram per day.Has anyone had negative side effects we should look for?"

http://www.resforum.org/index&…..dl-i-take/

Post edited 8:27 am – November 16, 2009 by RevGenetics

I am glad you stated that you were Holmes, that certainly explains why you are very argumentative with me. It is embarrassing to see you try to push your products in this manner. You must be having a very bad year to use anonymous accounts to suggest your company and it's products. I suggest you change your formulation to include a 250mg capsule, instead of continuing with formulations using a lower amount. The fact is that the perception has changed, and 250mg is what folks are asking for and is acceptable.

I have been told about you, and it certainly appears you represent a competitor who I have dealt with legally in the past. To argue with you is simply a waste of my time, as I know your true intentions are not very admirable.

Dr. Sinclair says that doses over 250mg may be safe to take, and a personal choice.

A

Imminst.org:

is an international, not-for-profit, membership-based organization ("501-3-c status" in the United States).

More Information here:

http://www.imminst.org/about

As a non-profit they do different things to raise money for their projects, one of them is offer banner space for companies. At the end of the year, they have auctioned the space off and RevGenetics has simply won the auctions for a single banner in the resveratrol forum. I believe they are a remarkable organization, and have many discussions regarding different technologies that may help a person live longer. Most discussions are not about supplements, or resveratrol. Do biochemists post regularly on the imminst board? I would say they are one of many types of researchers that do post information on the board, so… yes.

The "500 club" was started back on January 16th, 2007 and has one of the best public records anywhere regarding folks that have taken 500mg (or more) of resveratrol a day. This January would be it's 3rd anniversary of resveratrol information just on this one thread. Most answers regarding this dosage are found here:

http://www.imminst.org/forum/5…..14124.html

That board has taken quote a bit of punishment from spam, and folks that create puppet accounts just to push their own products. In April of 2007, new rules had to be created because of these issues:

http://www.imminst.org/forum/C…..15491.html

Puppet accounts are simply anonymous accounts made to push a certain idea, or product. Folks at imminst.org have developed the vigilance to spot these types of accounts. The reason I believe that opendoor is so upset, is because he has been banned more than once there, simply because he has used puppet accounts to push certain products instead of providing useful information. It is pretty rare that a person get's banned or suspended from imminst.org forum. 

This board here is still in it's infancy, but will likely face the same issues.

In regards to the last post: I am not going to argue about the 500mg vs 250mg issue as I started out with 2000mg myself on October of 2006, and it was my option. I believe each of us makes our own mind up, and keeps certain things personal to oneself. I don't expect Dr. Sinclair to preside over opendoor's grievance, as dosage suggestions regarding resveratrol are simply that… suggestions. And what is good for an 18 year old couch potato may be very different than what is good for an athlete or a even a 65 year old person who suffers from many ailments and takes a handful of strong medications.

No, certain benefits are dose dependent… and certain issues require your doctor to consider the things you take very seriously. There is no generic dose for everyone, but there are suggestions for healthy people.

I have made my choice, have the funds to take micronized resveratrol myself, and I am 38 years old. It's certainly possible I choose differently when I am older, or when I combine it with other things that may make the resveratrol I do take much more potent. What do I tell my current customers? I tell them to look at the chart at the end of this article: http://store.revgenetics.com/k……asp?ID=36

Can the article change in the future? Sure, when we have more information about resveratrol.

Cheers

A

This question has already been answered by Dr. Sinclair here and elsewhere. Other regular Resveratrol users have also asserted their opinions based on their subjective experiences and comprehensive interpretation of published data combined with a review of users anecdotal reports. There simply is no sense beating a dead horse. The rec. dose is 250 mgs. as stated previously. It doesnt get any more specific than that. Okay?

Post edited 6:20 pm – November 9, 2009 by FM2020

RevGenetics said:

There is a thread here that states the following from Dr. Sinclair, as the information is more recent than the eBook:

———–

This is what Dr. Sinclair wrote:

"Revegenetics – one reason may be that the human studies are only short term (~3 mo) and the long term effects of resveratrol in healthy people over years are not yet known. Taking more than 250 mg, therefore, is venturing into greater unknown territory, which might be safe but would be a personal choice."

Where does Dr. Sinclair say anything in that thread about taking up to 500mg, RevGenetics? The Immortality Institute where you advertise, just banned me for pointing out that you made a claim that doesn't seem to be supported by anything Dr. Sinclair wrote. The ban was for being argumentative, but to me it seemed that RevGenetics simply said something not supported here, and I wanted to get to the bottom of it. I'm sure Dr. Sinclair can help, though.  When someone without any knowledge of resveratrol asks what the optimal dose might be,  does what RevGenetics wrote reflect your views?

—————

(question by Adam23) "So there's no consensus on the optimal dose of this stuff to take? I didn't want to order any until I heard someone with some authority on the matter to comment? Any experts in the forum?"

(answer by RevGenetics) 

"Dr. Sinclair says that "the doses based on the mouse studies are 250 -500 mg per day" (From his site)

Dr. Maroon suggests between 250mg -500mg, but athletes should consider more. (From his book "The longevity Factor")"

Please remember one is a Researcher, and the other a Neurosurgeon for the Steelers…
A   [Anthony Lorea, President of RevGenetics]

————-

Hello Dr. Sinclair,

My understanding is that you took 320mg of resveratrol for a few years, at 5mg/kg.

RevGenetics posted on the Immortality Insitiute forum in response to a person who wondered what the optimum dose might be:

"Dr. Sinclair says that "the doses based on the mouse studies are 250 -500 mg per day" (From his site)

Dr. Maroon suggests between 250mg -500mg, but athletes should consider more. (From his book "The longevity Factor")"

I'm confused. In your ebook, you say consider no more than 250mg. Do you recommend 250mg- 500mg?

Also, have you reconsidered the 5mg/kg dose when you said you were taking 320mg  a day fotr three years?

Thanks!